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.The latter phenomenon is not mediated by N- methyl-D-aspartate (NMDA)-,kainate- or quisqualate- preferring receptors, but is stimulated by ibotenic acid.Excitatory amino acid-stimulated D-(3H)aspartate release is antagonised byL-serine-O-phosphate and riluzole.These compounds did not block potassium-stimulated D-(3H)aspartate release.51-RILU0028 Serrano A; D'Angio M; Scatton B NMDA antagonists block restraint-inducedincrease in extracellular DOPAC in rat nucleus accumbens.(ENG) EUR J PHARMACOL (1989) 162(1) 157-66, 49REF The effects of the N-methyl-D-aspartate (NMDA) receptor antagonists CPP,TCP, PK 26124 and ifenprodil, and of the minor tranquillizer diazepam on stress-inducedchanges of dopamine metabolism in the nucleus accumbens were investigated in the rat.Dopamine metabolism was assessed by measuring the extracellular levels of 3,4-dihydroxyphenylacetic acid (DOPAC) by means of in vivo differential pulse voltammetry withelectrochemically pretreated carbon fiber clectrodes.Physical immobilization of the ratsfor 4 min caused a marked and long-lasting increase in extracellular DOPAC levels in thenucleus accumbens.A similar, though shorter-lasting, augmentation of extracellular DOPACwas observed in the nucleus accumbens after systemic administration of the anxiogenicagent methyl- beta-carboline-3-carboxylate (beta-(CCM) (10 mg/kg s.c.).Pretreatment withCPP (1 mg/kg i.p.), TCP (3 mg/kg i.p.), PK 26124 (3 mg/kg i.p.), ifenprodil (3 mg/kg i.p.)or diazepam (2 mg/kg i.p.) totally antagonized the immobilization-induced increase inextracellular DOPAC in the nucleus accumbens.52 - RILU0031 Baruch P; Artaud F; Godeheu G; Barbeito L; Glowinski J; Cheramy ASubstance p and neurokinin A regulate by different mechanisms dopamine release fromdendrites and nerve terminals of the nigrostriatal dopaminergic neurons.(ENG)NEUROSCIENCE, (1988) 25 (3) 889-898, 78REF Numerous striatal neurons innervating thesubstantia nigra contain substance P and/or neurokinin A.In contrast to substance P orneurokinin A, little neurokinin B is found in the substantia nigra.This led us to comparethe effects of nigral application of these tachykinins on the release of dopamine fromdendrites and nerve terminals of nigrostriatal dopaminergic neurons.Experiments were madein halothane-anesthetized cats implanted with one push-pull cannula in the substantianigra and another in the ipsilateral caudate nucleus (3H) Tyrosine was deliveredcontinuously to each push- pull cannula and the release of newly synthesized (3H) dopaminemeasured in the superfusate.The effects of substance P on (3H) dopamine release fromnerve terminals and dendrites were prevented when 2-amino- 6-trifluoromethoxybenzothiazole PK 26124 (10(-5) M), an antagonist of glutalnatergic transmission, wasapplied continuously into the caudate nucleus.In contrast, the stimulatory effects ofneurokinin A on (3H) dopamine release from nerve terminals and dendrites were insensitiveto 2-amino- 6-trifluoromcthoxy benzothiazole (10(-5) M).These results suggest thatneurokinin A, but not substance P, acts directly on dopaminergic cells.53 - RILU0033 Koek W; Woods JH 2-Amino-6-trifluoromethoxy benzothiazole (PK 26124), aproposed antagonist of excitatory amino acid neurotransmission, does not producephencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.(ENG)NEOROPHARMACOLOGY, (1988) 27 (7) 771-775, 10REF PK 26124, a proposed excitatory amino acidantagonist, was compared to mephenesin and phencyclidine (PCP).In pigeons, PK 26124 andmephenesin produced loss of righting that was to some extent associated with eye closureand muscle relaxation, whereas PCP produced catalepsy.PK 26124, but not mephenesin,produced PCP-like discriminative stimulus effects in some but not all pigeons 1n rats, PK26124 and mephenesin produced loss of righting but did not induce locomotion, sniffing,swaying and falling, unlike PCP.In rhesus monkeys, PK 26124 did not induce ketamine-likediscriminative stimulus effects.54-RILU0035 Rataud J; Bardone MC; Stutzmann JM; Mazadier M; Uzan A; Blanchard JCRiluzole (PK26124) induces discriminative stimuli in rats (ENG) PSYCHOPHORMACOLOGY, (1988)96 (SUPPL) 373 AB: 34.01.38 16TH CINP CONGRESS, MUNICH, 15-19/08/88,ABSTRACTS The possiblediscriminative properties of riluzole (PK 26124) administered po or ip, were studied inmale rats.The stimulation was not dependent on the route of administration.In contrastMK 801 did not generalize to the riluzole discriminative cue.Although its mode of actionis not yet known riluzole possesses discriminative properties which differs from MK 801.55 - RILU0061 Drejer J; Honore T; Schousboe A Excitatory amino acid-induced release of3H-GABA from cultured mouse cerebral cortex interneurons(ENG) J NEUROSCI, (1987) 7 (9)2910-2918, 31REF A newly developed continuous superfusion model was used for studies of3H-GABA release from cultured mouse cerebral cortex neurons.It was round that a series ofexcitatory amino acids (EAAs) representing all receptor subtypes evoked CA+2-depcndcntrelease of 3H-GABA from the neurons.Quisqualate was the most potent antagonist tested,then, L-glutamate, N-methyl-D-aspartate (NMDA), and kainate.The EAA-evoked 3H-GABArelease could be blocked by a series of EAA antagonists.The highly selective NMDAantagonist D-2-amino-5-phosphonovalcric acid was found to block NMDA responses, whereasthe nonselective antagonists cis-2,3-piperidinc dicarboxylic acid andgamma-D-glutamyl-aminomethyl sulphonic acid blocked responses to all agonists
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